Page 6 - OxyBand Research Background
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Journal of Burn Care & Research
         218    Lairet et al                                                                 May/June 2014



           It is not possible, based on the results of this study   Medical Materiel Agency for their administrative support
         alone, to conclude that the advantages of the Oxy-  and critical review of the article.
         Band  dressing  were  solely  because  of  the  oxygen
         content; other characteristics of the dressing may   REFERENCES
         have contributed to our observations. For example,
         the OxyBand dressing provides a more moist envi-     1.  Hopf HW, Gibson JJ, Angeles AP, et al. Hyperoxia and an-
                                                               giogenesis. Wound Repair Regen 2005;13:558–64.
         ronment; this may contribute to wound healing. In     2.  Whitney, JD. Physiological effects of tissue oxygenation on
         addition, the OxyBand dressing does not adhere        wounds. Heart Lung. 1989; 18(5):466–74.
         as much to the wound bed, which may contribute       3.  Gordillo GM, Sen CK. Revisiting the essential role of oxy-
                                                               gen in wound healing. Am J Surg 2003;186:259–63.
         to reduced pain. A placebo dressing containing air     4.  Rahat MA, Marom B, Bitterman H, Weiss-Cerem L, Kinarty
         rather than oxygen was not available for this study.   A, Lahat N. Hypoxia reduces the output of matrix metal-
         Also, we did not measure oxygen levels at the wound   loproteinase-9 (MMP-9) in monocytes by inhibiting its se-
         surface. These factors represent limitations in the   cretion and elevating membranal association. J Leukoc Biol
                                                               2006;79:706–18.
         design of our study.                                 5.  Tandara AA, Mustoe TA. Oxygen in wound healing—more
           For skin donor sites in burn patients, we conclude   than a nutrient. World J Surg. 2004;28(3):294–300.
         that use of an oxygen-diffusion dressing was associated     6.  Said HK, Hijjawi J, Roy N, Mogford J, Mustoe T. Transdermal
                                                               sustained-delivery  oxygen improves  epithelial  healing  in a
         with, on average, a 3-day decrease in wound healing   rabbit ear model. Arch Surg. 2005;140(10):998–1004.
         time as well as a decrease in postoperative pain.    7.  Wright TE, Payne WG, Ladizinsky D, et al The effects of an
                                                               oxygen-generating dressing on tissue infection and wound
                                                               healing. J Appl Res Fall. 2003;3(4):363–70.
         ACKNOWLEDGMENTS                                      8.  Thackham  JA, McElwain  DL, Long RJ. The  use of hy-
                                                               perbaric oxygen therapy to treat chronic wounds. Wound
         The authors acknowledge the dedicated work of the     Repair Regen. 2008;16(3):321–30.
         Clinical Trials Research Nurse Team to include Cathy     9.  Kalliainen LK, Gordillo GM, Schlanger R, Sen CK. Topical
                                                               oxygen as an adjunct to wound healing: a clinical case series.
         Rauschendorfer, Bryan Jordan, Elsa Coates, Erica Pam-  Pathophysiology 2003;9:81–7.
         plin, and Victoria Hatem during this study. Drs. Jonathan     10.  Feldmeier JJ, Hopf HW, Warriner RA 3rd, Fife CE, Gesell
         Lundy and Rodney Chan evaluated the final cosmetic    LB, Bennett M. Undersea Hyperbaric Medicine Society
         appearance of the wounds at 30 to 45 days; the authors   (UHMS) position statement: topical oxygen for chronic
                                                               wounds. Undersea Hyperb Med. 2005;32(3):157–68.
         are grateful for their work and time. Thanks to Mr. John     11.  Yeong EK, Mann R, Engrav LH, et al. Improved burn scar
         Jones for statistical support. The authors also thank Ms.   assessment with the use of a new scar-rating scale. J Burn
         Patricia Dubill and Mr. Greggory Housler of U.S. Army   Care Rehab. 1997;18(4):353–5.
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