Page 12 - OxyBand Research Background

OxyBand Dressing Accelerates Wound Healing

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OxyBand Dressing Accelerates Wound Healing

in Two Randomized Controlled Trials

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Stanley Poulos, MD , Gerit Mulder, DPM MS , Cynthia Goodman,MD
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1 Aesthetic Plastic Surgery Center, 1240 South Eliseo Drive, Suite 201, Greenbrae, CA 94904;
2 Associate Professor of Surgery and Orthopedics, and Director of the Wound Treatment and
Research Center, University of California San Diego Medical Center, 200 West Arbor Drive, San
Diego, CA 92103
3 Chief Plastic Surgery Marin General Hospital, 250 Bon Air Road, Greenbrae, CA 94904

*Background Report for publication

Keywords: Wound, oxygen, dressing, burns, acute, superficial, laser, aesthetic, plastic
surgery, epithelialization

ABSTRACT:
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The efficacy of the OxyBand , a novel wound dressing pre-filled with oxygen, is

evaluated in two clinical studies of epithelialization of burn wounds on healthy
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volunteers. The OxyBand wound dressing is compared to a standard polyurethane
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dressing, Tegaderm and to an identical placebo dressing after superficial Erbium
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laser burns where patients served as their own controls. The OxyBand v. Tegaderm

study was conducted on 30 paired control/test wounds 5mm in diameter (total area 19.6
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mm ) with 50-micron ablation/25-micron coagulation. The OxyBand (95% oxygen) v.
placebo (21% oxygen, simulating air) study was conducted on 19 paired control/test
wounds, 25.4 mm square shape (total area 645 mm ) with 100-micron ablation/25-
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micron coagulation. Results showed the area of wound epithelialized by day 3 were
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12.8 mm for Oxyband and 4.9 mm for Tegaderm treated wounds, and by day 7
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were 17.8 mm and 14.1 mm for Oxyband and Tegaderm , respectively. Wounds
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treated with OxyBand healed 28.4% faster compared to the wounds treated with a
placebo dressing (mean time to 100% epithelialization was 6.2 days + 0.9 for

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OxyBand treated wounds and 8.8 days + 0.7 for placebo treated wounds). In addition,
perceived pain, redness, and level of exudate formation was less in wounds treated with
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the Oxyband wound dressing compared to placebo dressing. The results of the

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