Page 24 - OxyBand Research Background

OxyBand Dressing Accelerates Wound Healing

Scars were evaluated 30 days after the laser procedure. As would be
expected in a wound of this type, there was minimal visible scarring. However, there

were differences observed in the appearance of scars 30 days after the procedure for

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OxyBand treated wounds compared to placebo treated wounds. Scored on scale from
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0 to 5 (0 being no scar), the OxyBand mean scar score, 1.2 (0 – 5 Scale), 30 days
post procedure compared to the placebo mean scar score, 2.3 (0 – 5 Scale), 30 days
post procedure. A significant difference, 1.1 was found between the mean scar scores.

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The scar from the OxyBand treated wound had 48% better visual scar appearance at
30-days post laser procedure than scar from the placebo treated wound. A few of the
subjects in the present study returned after 90 days (not required) for scar evaluation.

Although there were not enough subjects to show statistical significance, a more
dramatic difference was seen in the scar appearance between the OxyBand and
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placebo treated wounds for the subjects that did return for the additional follow-up at 90
days post laser.

DISCUSSION:

Previous studies have demonstrated the importance of oxygen in accelerating
wound healing and decreasing infection in both acute and chronic wounds. Standard

wound dressings often block or reduce oxygen access to the wounds, creating a further
oxygen deficiency for wounds. When wounds are hypoxic, they are impaired in their

resistance to infection (Hopf et al., 1997), in fibroblast activity (Jonsson et al., 1986;

Silver, 1973), collagen deposition (Hunt & Pai, 1972), angiogenesis (Gibson et al.,
1997) and epithelialization (Niinikoski et al., 1983) The tradeoffs associated with

oxygen treatment with hyperbaric chambers such as cost, time consuming treatment
schedules, toxicity, CNS complications is well documented and makes this therapy

impractical for treating most acute wounds. Other topical modalities have various

limitations such as having to be tethered or battery powered oxygen source,
uncontrolled oxygen delivery, inability to achieve or sustain high oxygen levels.

OxyBand technology is based on the principal of oxygen diffusion from a
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higher oxygen tension to a lower oxygen tension in the wound. OxyBand dressings
containing oxygen gas were applied to the wound bed with the permeable membrane

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