Page 25 - OxyBand Research Background

OxyBand Dressing Accelerates Wound Healing

placed in contact with the wound interface, sealing circumferentially to be occlusive to
outside bacteria and loss of oxygen. Although oxygen tension in the healing wounds for

these studies was not measured, previous benchtop testing of the dressing indicates

that oxygen transfer from the reservoir to the target site is diffusion controlled, the
oxygen levels across the film increase rapidly, level out and is sustained over multiple

days, dropping less than 5% per day. Testing was conducted over 6 days on a
customized test bed that incorporated an MI- 730 Microelectrode oxygen sensor

TM
(Microelectrodes, Inc. Bedford, NH). This suggests that OxyBand can deliver oxygen
continuously to a wound bed for multiple days. It therefore follows that such a dressing
could provide beneficial effects of oxygen to a standardized burn wound as it holds the

oxygen over the wound. The bottom layer is a high transfer rate polyurethane film,
allowing oxygen to diffuse into the wound until the wound fluid is saturated with oxygen.

The dressing acts like an oxygen reservoir allowing the wound to utilize as much
oxygen as needed rather than being limited to atmospheric levels.

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The ease of use applying a simple OxyBand dressing to administer high
concentrations of oxygen over multiple days was noted in both trials.

CONCLUSION:

In two studies, we have shown that the use of OxyBand wound dressings for
TM
up to 7 days in superficial burn wounds results in a statistically significant enhancement

in the speed of wound re-epithelialization, and a correlative decrease in pain. The first
study used the standard polyurethane dressing, Tegaderm TM as the control. The

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second study was a double blind randomized, controlled trial comparing the OxyBand
dressing to a placebo dressing on standardized wounds, which also demonstrated an

impressive difference in the speed of wound re-epithelialization of wounds as well as a
correlative decrease in pain, exudate, redness and scar appearance 30 days later.

Taken together, these randomized controlled clinical trials on simple
standardized wounds suggest that the improved outcomes demonstrated for the

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