Page 36 - OxyBand Research Background

Oxygen Reservoir Dressing Sustains Elevated Wound
pO2 After Hyperbaric Oxygen Treatment

3
Harriet Hopf, MD , Gerit Mulder, DPM , Jay Duchnick, CHT , Scott Barnhill, AS, SRS, RLATG
1
2

1 University of Utah Dept of Anesthesiology , 2 UCSD Wound Treatment and Research Center, 3 UCSD Hyperbaric Medicine Dept
Introduction Methods
The benefits of hyperbaric oxygen With IACUC approval, 8 standardized full thickness
therapy (HBOT) for wound healing are wounds were created on the back of 2 pigs (one
well established and result from the normobaric control, one HBOT). The wounds
oxidant effects of oxygen and biologic were covered with either thin film (4 per pig) or
processes for which oxygen is a rate- OxyBand TM (4 per pig) dressings. Oxygen levels at
limiting step. Although the major 4+/-2mm depth within the wound exudate were
benefits of HBOT clearly result from measured 3, 8, 11.5, 14, and 16 hours after
systemic oxygen delivery, the potential dressing placement and 15 min, 2, 6, and 12
benefits of topical oxygen are also of hours after HBOT using polarographic
interest. We therefore evaluated an microelectrodes.
oxygen reservoir dressing (OxyBand TM ) Results
for its ability to maintain elevated levels
of dissolved oxygen (PO 2 ) in wounds With the pigs intubated and anesthetized (FiO2
after HBOT. The oxygen is stored in 1.0), the PO2 ranged from 81-106 mmHg under
between an occlusive upper layer and a the control dressing and 160-228 mm Hg under
lower permeable film, which allows the the test dressing. PO2 was 256-260 mmHg
dressing to supersaturate the wound under both dressings 15 min after HBOT. At 2-12
fluid with regenerative oxygen for days at hours after HBOT, PO2 was 89-125 mmHg under
a time. the control dressing and 245-263 mmHg under
the test dressing.
Conclusions
The OxyBand TM reservoir dressing maintained
elevated wound oxygen levels after HBOT,
demonstrating that the dressing was able to
replenish oxygen levels as it was consumed
locally. Potential synergies of providing the Acknowledgments and Disclosures
Stacy Davis and Ryan McMurray at UCSD tested pump accuracy
systemic benefits of HBOT and extending the local OxyHeal Health Group, Inc. National City, CA donated HBO chamber use

benefits of hyperoxia using an on-demand oxygen Oxyband Technologies, Inc, San Diego, CA donated dressings

reservoir dressing warrants further investigation. Drs. Hopf has received research funding from Oxyband